Clinical Results

ARESTIN® + SRP:
Therapeutic drug concentrations lead to better clinical outcomes than SRP alone at 30 days

Reduces harmful bacteria

Reduces pocket depth

Reduces inflammation

* Single-blind, randomized, parallel-group study of 127 patients with moderate-to-severe periodontitis who had at least 5 teeth with ‚â• 5 mm pocket depths. Mean RCB numbers were reduced from 18.9 x 10⁵ to 9.50 x 10⁵ (50%) by ARESTIN® + SRP and from 19.3 x 10⁵ to 14.2 x 10⁵ (26%) by SRP alone.

a. Mean changes from baseline to Day 30 for ARESTIN® + SRP vs SRP alone were: pocket depth reduction, 1.38 mm vs 1.01 mm; reduction in percent of sites with bleeding on probing, 25.2% vs 13.8%. Percent improvement was based on the difference in mean change with ARESTIN® + SRP vs SRP alone, calculated with the mean change of SRP alone as the denominator.

1. Goodson JM, Gunsolley JC, Grossi SG, et al. Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy. J Periodontol 2007;78:1568-1579.